南京大学，生命科学学院，教授

从事炎症性肠病及肠炎诱发的癌症等相关疾病的发病机制探讨及治疗策略研究，阐明特定免疫细胞种群中的关键蛋白及非编码核酸在肠道炎性疾病过程中的重要作用；并以上述关键细胞和分子作为靶点，开展治疗研究，取得很好疗效，以第一作者和通讯作者发表论文20余篇，包括胃肠病学和生物治疗领域的重要期刊Gut，Mucosal Immunology和Molecular Therapy等，主持国家自然科学基金项目3项。

教育经历：

2008-09至2013-06，南京大学，生命科学学院，博士，导师：张峻峰

2004-09至2008-06，南京大学，生命科学学院，学士

研究工作经历：

2022-01至现在，   南京大学，生命科学学院，教授

2015-09至2021-12，南京大学，生命科学学院，副教授

2013-07至2015-08，南京大学，生命科学学院，博士后

 炎症性肠炎及肠病发病机制研究

[1] Shiliang Ji, Feifan Wang, Yongjie Wu, Haoran Hu, Zhen Xing, Jie Zhu, Shi Xu, Tiyun Han, Guilai Liu, Zengding Wu, Caiyi Fei, Lingming Kong, Jiangning Chen, Zhi Ding*, Zhen Huang*, Junfeng Zhang*. Large-scale transcript variants dictate neoepitopes for cancer immunotherapy. Sci Adv. 2025;11(5):eado5600.

[2] Mingming Zhao, Xiaohui Cheng, Pingwen Shao, Yao Dong, Yongjie Wu, Lin Xiao, Zhiying Cui, Xuedi Sun, Chuancheng Gao, Jiangning Chen*, Zhen Huang*, Junfeng Zhang*. Bacterial protoplast-derived nanovesicles carrying CRISPR-Cas9 tools re-educate tumor-associated macrophages for enhanced cancer immunotherapy. Nat Commun. 2024;15(1):950.

[3] Xiaohui Cheng, Pingwen Shao, XinTong Wang, Juan Jiang, Jiahui Chen, Jie Zhu, Weiming Zhu, Yi Li*, Junfeng Zhang*, Jiangning Chen*, Zhen Huang*. Myeloid-Derived Suppressor Cell Accumulation Drives Intestinal Fibrosis through mCCL6/hCCL15 Chemokine-Mediated Fibroblast Activation. Adv Sci (Weinh). 2024:e2411711.

[4] Chen Wang, Ziyu Shi, Yuqian Zhang, Mingyue Li , Jie Zhu, Zhen Huang*, Junfeng Zhang*, Jiangning Chen*. CBFβ promotes colorectal cancer progression through transcriptionally activating OPN, FAM129A, and UPP1 in a RUNX2-dependent manner. Cell Death Differ. 2021;28(11):3176-3192.     

[5] Zhen Huang, Tongguo Shi, Qian Zhou, Song Shi, Ran Zhao, Hao Shi, Lei Dong, Chenyu Zhang, Ke Zeng, Jiangning Chen, Junfeng Zhang. MiR-141 Regulates colonic leukocytic trafficking by targeting CXCL12beta during murine colitis and human Crohn's disease. Gut. 63:1247-57, 2014.